This presentation will provide an overview of the state of the science in the development, evaluation and implementation of mobile technology-based therapeutic interventions to provide anytime/anywhere science-based prevention and treatment for opioid use disorders. These tools are designed to deliver engaging and effective interventions and to collectively lead to transformations in the delivery of science-based care for substance use disorders. The goal is to improve quality of care, access to care and clinical outcomes, while reducing costs of care.