Clinical Decision Support (CDS) is an essential piece of the healthcare informatics playbook. Healthcare informaticists are routinely asked for new and improved CDS to help support clinicians’ workflow and incorporate best practices from a clinical and regulatory perspective. Due to this, as well as constant changes in software updates, and regulatory and clinical changes, including drug shortages, it is important to have a governance system in place to manage the intricacies of CDS evaluation and implementation. This presentation will discuss the multifactorial evaluation of CDS prior to design and programming to incorporate the evaluation of the overall impact of the CDS, the location within the clinicians’ workflow, and how to measure outcomes and monitor performance and utilization of the CDS. Other topics discussed will be some of the influences that impact CDS and ways to coordinate the governance of these types of inputs, as well as the importance of standardization, interoperability standards, required vs. recommended decisions and coordination with clinicians and other teams.